Development of a computational paradigm for laser treatment of cancer

J. T. Oden*, K. R. Diller, C. Bajaj, J. C. Browne, J. Hazle, I. Babuška, J. Bass, L. Demkowicz, Y. Feng, D. Fuentes, Serge Prudhomme, M. N. Rylander, R. J. Stafford, Y. Zhang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

11 Scopus citations

Abstract

The goal of this project is to develop a dynamic data-driven planning and control system for laser treatment of cancer. The research includes (1) development of a general mathematical framework and a family of mathematical and computational models of bio-heat transfer, tissue damage, and tumor viability, (2) dynamic calibration, verification and validation processes based on laboratory and clinical data and simulated response, and (3) design of effective thermo-therapeutic protocols using model predictions. At the core of the proposed systems is the adaptive-feedback control of mathematical and computational models based on a posteriori estimates of errors in key quantities of interest, and modern Magnetic Resonance Temperature Imaging (MRTI), and diode laser devices to monitor treatment of tumors in laboratory animals. This approach enables an automated systematic model selection process based on acceptance criteria determined a priori. The methodologies to be implemented involve uncertainty quantification methods designed to provide an innovative, data-driven, patient-specific approach to effective cancer treatment.

Original languageEnglish (US)
Title of host publicationComputational Science - ICCS 2006
Subtitle of host publication6th International Conference, Proceedings
PublisherSpringer Verlag
Pages530-537
Number of pages8
ISBN (Print)3540343830, 9783540343837
DOIs
StatePublished - Jan 1 2006
EventICCS 2006: 6th International Conference on Computational Science - Reading, United Kingdom
Duration: May 28 2006May 31 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3993 LNCS - III
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

OtherICCS 2006: 6th International Conference on Computational Science
CountryUnited Kingdom
CityReading
Period05/28/0605/31/06

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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