Development and application of polymeric monolithic stationary phases for capillary electrochromatography

Emily F. Hilder, Frantisek Svec*, Jean Frechet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

212 Scopus citations

Abstract

Monolithic columns for capillary electrochromatography are receiving quite remarkable attention. This review summarizes results excerpted from numerous papers concerning this rapidly growing area with a focus on monoliths prepared from synthetic polymers. Both the simplicity of the in situ preparation and the large number of readily available chemistries make the monolithic separation media a vital alternative to capillary columns packed with particulate materials. Therefore, they are now a well-established stationary phase format in the field of capillary electrochromatography. A wide variety of synthetic approaches as well as materials used for the preparation of the monolithic stationary phases are presented in detail. The analytical potential of these columns is demonstrated with separations involving various families of compounds and different chromatographic modes.

Original languageEnglish (US)
Pages (from-to)3-22
Number of pages20
JournalJournal of Chromatography A
Volume1044
Issue number1-2
DOIs
StatePublished - Jul 30 2004

Keywords

  • Electrochromatography
  • Monolithic columns
  • Peptides
  • Proteins
  • Reviews
  • Saccharides
  • Stationary phases, electrochromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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