Designing dendrimers for drug delivery

Mingjun Liu, Jean Frechet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

413 Scopus citations

Abstract

Dendrimers are highly branched three-dimensional macromolecules with highly controlled structures, a single molecular weight, a large number of controllable 'peripheral' functionalities and a tendency to adopt a globular shape once a certain size is reached. These features have made their application in pharmaceutical and medicinal chemistry particularly attractive. This review briefly discusses the preparation of dendrimers, their use as gene delivery agents and magnetic resonance imaging agents, and their potential for applications in drug delivery. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)393-401
Number of pages9
JournalPharmaceutical Science and Technology Today
Volume2
Issue number10
DOIs
StatePublished - Oct 1 1999

ASJC Scopus subject areas

  • Pharmaceutical Science

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