Design of emission ratiometric metal-ion sensors with enhanced two-photon cross section and brightness

S. Sumalekshmy, Maged M. Henary, Nisan Siegel, Pa Dreyia V. Lawson, Yonggang Wu, Karin Schmidt, Jean-Luc Bredas*, Joseph W. Perry, Christoph J. Fahrni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

To develop metal-responsive fluorescence probes with optimized nonlinear optical properties for two-photon excitation fluorescence microscopy (TPEM), we investigated the utility of donor-acceptor architectures where the metal-ion coordinates to the acceptor rather than donor site of the fluorophore. Zn(II) binding to such a probe consisting of a tris(picolyl)amine-substituted acceptor site connected with an anisole donor moiety and an oxazole central core resulted in a significant increase of the two-photon absorption cross section (δ) and fluorescence brightness (ηδ). The fluorophore showed also a strong shift of the emission peak upon saturation with Zn(II), rendering the proposed approach suitable for two-photon excited emission ratiometric sensing.

Original languageEnglish (US)
Pages (from-to)11888-11889
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number39
DOIs
StatePublished - Oct 3 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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