Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3

Britt Marie Swahn*, Yafeng Xue, Erwan Arzel, Elisabet Kallin, Angelika Magnus, Niklas Plobeck, Jenny Viklund

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    49 Scopus citations

    Abstract

    The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2′-anilino-4,4′-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.

    Original languageEnglish (US)
    Pages (from-to)1397-1401
    Number of pages5
    JournalBioorganic and Medicinal Chemistry Letters
    Volume16
    Issue number5
    DOIs
    StatePublished - Mar 1 2006

    Keywords

    • 2′-Anilino-4,4′- bipyridines
    • JNK3 inhibitors
    • Structure based design
    • Structure-activity relationship
    • c-Jun N-terminal kinase-3

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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