Derivation of two naturally isogenic iPSC lines (KAUSTi006-A and KAUSTi006-B) from a mosaic Klinefelter Syndrome patient (47-XXY/46-XY).

Elisabetta Fiacco, Maryam Alowaysi, Veronica Astro, Antonio Adamo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

While Klinefelter Syndrome (KS) has a prevalence of 85-250 per 100,000 born males, patients are typically underdiagnosed due to a subtle phenotype emerging only late during puberty or adulthood. Rare cases of KS carry a mosaic phenotype 47-XXY/46-XY associated to mild phenotypic traits mostly compatible with a normal life including preserved fertility. From a genetic modeling perspective, the derivation of naturally isogenic iPSCs from mosaic patients allows the comparison of disease and healthy cells carrying a virtually identical genomic background.
Original languageEnglish (US)
Pages (from-to)102049
JournalStem Cell Research
Volume49
DOIs
StatePublished - Oct 23 2020

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