Dependence of pharmacokinetics and biodistribution on polymer architecture: Effect of cyclic versus Linear polymers

Norased Nasongkia*, Bo Chen, Nichole Macaraeg, Megan E. Fox, Jean Frechet, Francis C. Szoka

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

169 Scopus citations

Abstract

The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable molecular weight.

Original languageEnglish (US)
Pages (from-to)3842-3843
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number11
DOIs
StatePublished - Mar 25 2009

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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