Dendritic carrier based on PEG: Design and degradation of acid-sensitive dendrimer-like poly(ethylene oxide)s

Xiaoshuang Feng, Elliot L. Chaikof, Christelle Absalon, Carlos Drummond, Daniel Taton*, Yves Gnanou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Degradable dendrimer-like PEOs were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 k·mol -1 was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (≈2k·mol -1 ), as monitored by 1 H NMR, SEC, and MALDI-TOF mass spectrometry as well as by AFM.

Original languageEnglish (US)
Pages (from-to)1722-1728
Number of pages7
JournalMacromolecular Rapid Communications
Volume32
Issue number21
DOIs
StatePublished - Nov 1 2011

Keywords

  • biodegradable
  • branching
  • dendrimer
  • ketal
  • poly(ethylene oxide)

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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