Dendrimers and dendritic polymers in drug delivery

Elizabeth R. Gillies*, Jean Frechet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1120 Scopus citations

Abstract

The unique properties of dendrimers, such as their high degree of branching, multivalency, globular architecture and well-defined molecular weight, make them promising new scaffolds for drug delivery. In the past decade, research has increased on the design and synthesis of biocompatible dendrimers and their application to many areas of bioscience including drug delivery, immunology and the development of vaccines, antimicrobials and antivirals. Recent progress has been made in the application of biocompatible dendrimers to cancer treatment, including their use as delivery systems for potent anticancer drugs such as cisplatin and doxorubicin, as well as agents for both boron neutron capture therapy and photodynamic therapy.

Original languageEnglish (US)
Pages (from-to)35-43
Number of pages9
JournalDrug Discovery Today
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2005

Keywords

  • Biochemistry
  • Biocompatible
  • Boron neutron capture therapy
  • Cancer
  • Cancer biology
  • Dendrimer-drug conjugates
  • Drug Discovery
  • Pharmaceutical Science
  • Photodynamic therapy

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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