Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties

Shyam M. Rele*, Wanxing Cui, Lianchun Wang, Sijian Hou, Ginger Barr-Zarse, Daniel Tatton, Yves Gnanou, Jeffrey D. Esko, Elliot L. Chaikof

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 10 3 -fold greater activity than other multivalent sLe x glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.

Original languageEnglish (US)
Pages (from-to)10132-10133
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number29
DOIs
StatePublished - Jul 27 2005

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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