Degradable dextran particles for gene delivery applications

Peter R. Wich, Jean Frechet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Successful gene therapy depends both on the effective transport and the stable expression of therapeutic genes to produce and regulate disease related proteins. In this context, non-viral gene delivery vehicles are regarded as one of the most promising approaches for the efficient and safe transport of genetic material to and into the target cells. This short review describes the development of novel particulate delivery vehicles based on the biopolymer dextran. This multifunctional platform was designed to safely transport genetic material across cell membranes, followed by an acid triggered release that causes overall high transfection efficiency. The biocompatibility and its unique tunability differentiate this new carrier system from previous particle systems, showing high potential for the treatment of several disease models in RNA interference related applications. Journal compilation

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalAustralian Journal of Chemistry
Volume65
Issue number1
DOIs
StatePublished - Feb 16 2012

ASJC Scopus subject areas

  • Chemistry(all)

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