Deconstructing the pluripotency gene regulatory network

Mo Li, Juan Carlos Izpisua Belmonte

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Pluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an interconnected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-binding proteins and alternative splicing, as an important regulatory layer of pluripotency. We also discuss heterogeneity in pluripotency regulation, alternative pluripotency states and future directions of pluripotent stem cell research.
Original languageEnglish (US)
Pages (from-to)382-392
Number of pages11
JournalNature Cell Biology
Issue number4
StatePublished - Mar 28 2018


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