Dearomatization of 3-Nitroindoles by a Phosphine-Catalyzed Enantioselective [3+2] Annulation Reaction

Kaizhi Li, Theo Goncalves, Kuo-Wei Huang, Yixin Lu

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

The dearomatization of 3-nitroindoles through a chiral-phosphine-mediated [3+2] annulation reaction is described. This method makes use of readily available 3-nitroindoles as an aromatic feedstock and rapidly delivers a wide range of cyclopentaindoline alkaloid scaffolds in a highly enantioselective manner. Notably, phosphine-triggered cyclization has not been utilized previously in a dearomatization process.
Original languageEnglish (US)
Pages (from-to)5427-5431
Number of pages5
JournalAngewandte Chemie International Edition
Volume58
Issue number16
DOIs
StatePublished - Mar 14 2019

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