Customized mesoporous metal organic frameworks engender stable enzymatic nanoreactors

Liwen Zhang, Walaa Baslyman, Peng Yang, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Here, the porosity of a metal organic framework (MIL-101) is tailored by the choice of the solvent occupying the pores in a template free acid etching process. Employing a slightly basic solvent such as DMF afforded big pores around 30 nm (BP-MIL-101). Catalase (CAT), which is a large protein (6 × 10 nm), was successfully encapsulated by a diffusion-based method with a high capacity of 12.5%. BP-MIL-101 could successfully protect CAT from both digestion and denaturation while maintaining its catalytic activity. This paves the way for encapsulating different large biological targets for eventual translation and delivery.
Original languageEnglish (US)
Pages (from-to)620-623
Number of pages4
JournalChemical Communications
Volume55
Issue number5
DOIs
StatePublished - 2019

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