Crystallisation behaviour of sugars precipitated by supercritical fluids

Andréanne Bouchard*, Nataša Jovanović, Daan J A Crommelin, Wim Jiskoot, Gerard W. Hofland, Geert Jan Witkamp

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aqueous solutions of common saccharides and polyols used by the pharmaceutical industry were spray dried in various concentrations with a co-current flow of supercritical carbon dioxide enriched with ethanol in a pressurised precipitation vessel, while keeping all other process conditions constant. The dry powders were recovered from a filter after pressure release. The residual water content was measured and the particle morphology and crystallinity were observed. Sucrose and mannitol were readily crystallised, but the trehalose was amorphous. The effect of viscosity and of hydrate formation is discussed.

Original languageEnglish (US)
Article numberD-9
Pages (from-to)817-822
Number of pages6
JournalVDI Berichte
Issue number1901 II
StatePublished - Nov 7 2005
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)

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