Cross-Coupling of Amides with Alkylboranes via Nickel-Catalyzed C–N Bond Cleavage

Xiangqian Liu, Chien-Chi Hsiao, Lin Guo, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

A protocol for the nickel-catalyzed alkylation of amides was established. The use of alkylboranes as nucleophilic partners allowed the use of mild reaction conditions and compatibility of various functional groups with respect to both coupling partners. The catalytic alkylation proceeded selectively at the amides in the presence of other functional groups as well as other carboxylic acid derived moieties.
Original languageEnglish (US)
Pages (from-to)2976-2979
Number of pages4
JournalOrganic Letters
Volume20
Issue number10
DOIs
StatePublished - May 9 2018

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