Copper catalyzed C-H functionalization for direct Mannich reactions

Magnus Rueping*, Nikita Tolstoluzhsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

135 Scopus citations

Abstract

A protocol for a practical and direct addition of α-and γ-alkyl azaarenes to N-sulfonyl aldimines has been developed. Copper salts act as efficient Lewis acid catalysts for direct Mannich-type reactions providing a mild and fast access to various functionalized heterocycles.(Figure Presented)

Original languageEnglish (US)
Pages (from-to)1095-1097
Number of pages3
JournalOrganic Letters
Volume13
Issue number5
DOIs
StatePublished - Mar 4 2011

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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