Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34

Peter Siman, Subramanian Vedhanarayanan Karthikeyan, Miroslav Nikolov, Wolfgang Fischle, Ashraf Brik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.

Original languageEnglish (US)
Pages (from-to)8059-8063
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number31
DOIs
StatePublished - Jul 29 2013

Keywords

  • H2B protein
  • chromatin
  • peptide ligation
  • proteins
  • ubiquitination

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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