Convergent catalysis: Asymmetric synthesis of dihydroquinolines using a combined metal catalysis and organocatalysis approach

Magnus Rueping*, Jeremy Dufour, Lan Bui

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A convergent catalysis approach has been developed. The combined metal-catalyzed and organocatalyzed cascade consists of two oxidations, an aza-Michael addition and an aldol condensation, and involves a multicatalysis approach to provide 1,2-dihydroquinolines in a highly enantioselective fashion.

Original languageEnglish (US)
Pages (from-to)1021-1025
Number of pages5
JournalACS Catalysis
Volume4
Issue number3
DOIs
StatePublished - Mar 7 2014

Keywords

  • Michael reaction
  • TPAP oxidation
  • aldol reaction
  • diphenylprolinol ether
  • domino reaction

ASJC Scopus subject areas

  • Catalysis

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