Continuous-flow hydration-condensation reaction: Synthesis of αβ-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

Magnus Rueping*, Teerawut Bootwicha, Hannah Baars, Erli Sugiono

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A simple, practical and efficient continuous-flow hydration-condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale.

Original languageEnglish (US)
Pages (from-to)1680-1687
Number of pages8
JournalBeilstein Journal of Organic Chemistry
Volume7
DOIs
StatePublished - Dec 15 2011

Keywords

  • Chalcones
  • Flow reactor
  • Green chemistry
  • Heterogeneous catalysis, microwave

ASJC Scopus subject areas

  • Organic Chemistry

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