Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis

Magnus Rueping*, Teerawut Bootwicha, Erli Sugiono

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

The asymmetric organocatalytic hydrogenation of benzoxazines, quinolines, quinoxalines and 3H-indoles in continuous-flow microreactors has been developed. Reaction monitoring was achieved by using an inline ReactIR flow cell, which allows fast and convenient optimization of reaction parameters. The reductions proceeded well, and the desired products were isolated in high yields and with excellent enantioselectivities.

Original languageEnglish (US)
Pages (from-to)300-307
Number of pages8
JournalBeilstein Journal of Organic Chemistry
Volume8
DOIs
StatePublished - Feb 23 2012

Keywords

  • Asymmetric reduction
  • Binolphosphoric acid
  • Brønsted acid
  • Hantzsch dihydropyridine
  • IR spectroscopy
  • Real-time analysis

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis'. Together they form a unique fingerprint.

Cite this