Constitutively active MPK4 helps to clarify its role in plant immunity

Jean Colcombet*, Souha Berriri, Heribert Hirt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Mitogen-activated protein kinase (MAPK) modules are often involved in stress responses and plant developmental processes. Among these MAPKs, MPK4 has a complex role in biotic stress signaling, cell division control and cytoskeletal organization. mpk4 knockout (KO) plants are dwarfed and very sick, making it difficult to distinguish between cause and effect of its phenotype. To overcome this difficulty, we developed mutations triggering constitutive MPK4 activity and created transgenic lines allowing phenotypic studies on a WT-like plant. By this approach, we confirmed that MPK4 functions as a negative regulator of pathogen defense, but our work also suggests that MPK4 interferes with stress signaling pathways at several distinct steps in pathogenassociated molecular pattern (PAMP)- triggered immunity (PTI) as well as in effector-triggered immunity (ETI). This study shows that CA mutations are valuable complementary tools to study MAPK signaling pathways in planta.

Original languageEnglish (US)
JournalPlant Signaling and Behavior
Volume8
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • Arabidopsis thaliana
  • Biotic stress
  • Constitutive activity
  • Mitogen activated protein kinase 4
  • Seudomonas syringae

ASJC Scopus subject areas

  • Plant Science

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