Conservation of Salmonella infection mechanisms in plants and animals

Adam Schikora*, Isabelle Virlogeux-Payant, Eduardo Bueso, Ana V. Garcia, Theodora Nilau, Amélie Charrier, Sandra Pelletier, Pierrette Menanteau, Manuela Baccarini, Philippe Velge, Heribert Hirt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Salmonella virulence in animals depends on effectors injected by Type III Secretion Systems (T3SSs). In this report we demonstrate that Salmonella mutants that are unable to deliver effectors are also compromised in infection of Arabidopsis thaliana plants. Transcriptome analysis revealed that in contrast to wild type bacteria, T3SS mutants of Salmonella are compromised in suppressing highly conserved Arabidopsis genes that play a prominent role during Salmonella infection of animals. We also found that Salmonella originating from infected plants are equally virulent for human cells and mice. These results indicate a high degree of conservation in the defense and infection mechanism of animal and plant hosts during Salmonella infection.

Original languageEnglish (US)
Article numbere24112
JournalPloS one
Volume6
Issue number9
DOIs
StatePublished - Sep 12 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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