Concealing cellular defects in pluripotent stem cells

Weiqi Zhang, Jing Qu, Keiichiro Suzuki, Guang Hui Liu*, Juan Carlos Izpisua Belmonte

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Inherent and acquired defects in gene expression, protein homeostasis, metabolic pathways, and organelle function are linked to aging and a wide range of human diseases. Although concealed or dormant in the embryonic stage, they often manifest later in life. We review and discuss recent observations on how somatic cells bearing specific phenotypic defects can be reprogrammed into a pluripotent state where most phenotypic abnormalities can be reset or tolerated. Gaining insights into the tolerance of cellular defects in pluripotent stem cells will facilitate our understanding of the properties of reprogrammed cells and may provide theoretical guidance for induced pluripotent stem cell based disease modeling and clinical therapies.

Original languageEnglish (US)
Pages (from-to)587-592
Number of pages6
JournalTrends in Cell Biology
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2013

Keywords

  • Disease modeling
  • Pluripotent stem cell
  • Reprogramming

ASJC Scopus subject areas

  • Cell Biology

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