Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the protease gene

K. Shimotohno, Y. Takahashi, N. Shimizu, Takashi Gojobori, D. W. Golde, I. S. Chen, M. Miwa, T. Sugimura

Research output: Contribution to journalArticlepeer-review

285 Scopus citations

Abstract

The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined. This provirus consists of 8952 nucleotides. In addition to long terminal reports and gag, pol, env, and X, a protease gene that is responsible for processing the gag precursor protein was found. The protease gene is encoded in a different frame from gag and pol and was located between the gag and pol open reading frames. The 5' region of the protease gene overlaps the 3' gag region. Coding regions of the provirus show about 60% homology with those of human T-cell leukemia virus type I at the nucleotide level. The evolutionary relationship between human T-cell leukemia virus types I and II is discussed.

Original languageEnglish (US)
Pages (from-to)3101-3105
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume82
Issue number10
DOIs
StatePublished - Sep 25 1985

ASJC Scopus subject areas

  • General

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