TY - JOUR
T1 - Cobalt ferrite supported on reduced graphene oxide as a T2 contrast agent for magnetic resonance imaging
AU - Alazmi, Amira
AU - Singaravelu, Venkatesh
AU - Batra, Nitin M
AU - Smajic, Jasmin
AU - Alyami, Mram Z.
AU - Khashab, Niveen M.
AU - Da Costa, Pedro M. F. J.
N1 - KAUST Repository Item: Exported on 2020-04-23
Acknowledgements: We are thankful for the financial support from KAUST (BAS/1/1346-01-01 and URF/1/3001-01-01). The technical support from the Core Labs at KAUST is appreciated. The TOC figure was created by Heno Hwang, scientific illustrator at KAUST.
PY - 2019
Y1 - 2019
N2 - Nanoscaled spinel-structured ferrites bear promise as next-generation contrast agents for magnetic resonance imaging. However, the small size of the particles commonly leads to colloidal instability under physiological conditions. To circumvent this problem, supports onto which the dispersed nanoparticles can be anchored have been proposed. Amongst these, flakes of graphene have shown interesting performance but it remains unknown if and how their surface texture and chemistry affect the magnetic properties and relaxation time (T2) of the ferrite nanoparticles. Here, it is shown that the type of graphene oxide (GO) precursor, used to make composites of cobalt ferrite (CoFe2O4) and reduced GO, influences greatly not just the T2 but also the average size, dispersion and magnetic behaviour of the grafted nanoparticles. Accordingly, and without compromising biocompatibility, a judicious choice of the initial GO precursor can result in the doubling of the proton relaxivity rate in this system.
AB - Nanoscaled spinel-structured ferrites bear promise as next-generation contrast agents for magnetic resonance imaging. However, the small size of the particles commonly leads to colloidal instability under physiological conditions. To circumvent this problem, supports onto which the dispersed nanoparticles can be anchored have been proposed. Amongst these, flakes of graphene have shown interesting performance but it remains unknown if and how their surface texture and chemistry affect the magnetic properties and relaxation time (T2) of the ferrite nanoparticles. Here, it is shown that the type of graphene oxide (GO) precursor, used to make composites of cobalt ferrite (CoFe2O4) and reduced GO, influences greatly not just the T2 but also the average size, dispersion and magnetic behaviour of the grafted nanoparticles. Accordingly, and without compromising biocompatibility, a judicious choice of the initial GO precursor can result in the doubling of the proton relaxivity rate in this system.
UR - http://hdl.handle.net/10754/631507
UR - https://pubs.rsc.org/en/Content/ArticleLanding/2019/RA/C8RA09476D#!divAbstract
UR - http://www.scopus.com/inward/record.url?scp=85062478319&partnerID=8YFLogxK
U2 - 10.1039/c8ra09476d
DO - 10.1039/c8ra09476d
M3 - Article
AN - SCOPUS:85062478319
VL - 9
SP - 6299
EP - 6309
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 11
ER -