Coatomer-dependent protein delivery to lipid droplets

Krishnakant G. Soni, Gonzalo A. Mardones, Rachid Sougrat, Elena Smirnova, Catherine L. Jackson*, Juan S. Bonifacino

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    166 Scopus citations

    Abstract

    Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly. Misregulation of LD function leads to many human diseases, including lipodystrophy, obesity and neutral lipid storage disorders. A number of proteins have been shown to localize to the surface of lipid droplets, including lipases such as adipose triglyceride lipase (ATGL) and the PAT-domain proteins ADRP (adipophilin) and TIP47, but the mechanism by which they are targeted to LDs is not known. Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators.

    Original languageEnglish (US)
    Pages (from-to)1834-1841
    Number of pages8
    JournalJournal of Cell Science
    Volume122
    Issue number11
    DOIs
    StatePublished - Jun 1 2009

    Keywords

    • ATGL
    • Lipid droplet
    • Lipid homeostasis

    ASJC Scopus subject areas

    • Cell Biology

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