Circulating haptoglobin is an independent prognostic factor in the sera of patients with epithelial ovarian cancer

Changqing Zhao, Loganath Annamalai, Changfa Guo, Narasimhan Kothandaraman, Stephen Chee Liang Koh, Huoming Zhang, Arijit Biswas, Mahesh Choolani*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    61 Scopus citations

    Abstract

    OBJECTIVE: This study was conducted to evaluate the prognostic significance of haptoglobin levels in the overall survival of patients presenting with various stages of epithelial ovarian cancer. MATERIALS AND METHODS: We employed an in-house sandwich enzyme-linked immunosorbent assay method to determine the concentrations of preoperative haptoglobin and C-reactive protein (CRP) in sera samples obtained from 66 malignant tumors, 60 benign tumors, and 10 normal healthy women. RESULTS: Levels of serum haptoglobin significantly correlated with tumor type (P < .001) and International Federation of Gynecology and Obstetrics stage (P < .05). A significant correlation was observed between clinical stage and patient survival (r = 5.99, P = .026). Our data also indicated that elevated serum haptoglobin levels were associated with poor outcome for overall survival using both univariate and multivariate analyses (P = .048 and P = .036 respectively). Using Pearson's correlation, we have noted that serum CRP concentrations significantly correlated with haptoglobin levels (r2 = 0.22, P < .001). Immunohistochemical findings and Western blot analyses were compatible with sera levels of haptoglobin in which a higher intensity of staining occurred in late-stage epithelial ovarian cancers. CONCLUSION: This study provides evidence that preoperative serum levels of haptoglobin could serve as an independent prognostic factor in patients presenting with epithelial ovarian cancer.

    Original languageEnglish (US)
    Pages (from-to)1-7
    Number of pages7
    JournalNeoplasia
    Volume9
    Issue number1
    DOIs
    StatePublished - Jan 1 2007

    Keywords

    • CRP levels
    • Epithelial ovarian cancer
    • Haptoglobin
    • Prognostic biomarker
    • Sandwich ELISA method

    ASJC Scopus subject areas

    • Cancer Research

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