Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription

Lorena Aguilar-Arnal, Paolo Sassone-Corsi

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Circadian rhythms drive the temporal organization of a wide variety of physiological and behavioral functions in ∼24-h cycles. This control is achieved through a complex program of gene expression. In mammals, the molecular clock machinery consists of interconnected transcriptional–translational feedback loops that ultimately ensure the proper oscillation of thousands of genes in a tissue-specific manner. To achieve circadian transcriptional control, chromatin remodelers serve the clock machinery by providing appropriate oscillations to the epigenome. Recent findings have revealed the presence of circadian interactomes, nuclear “hubs” of genome topology where coordinately expressed circadian genes physically interact in a spatial and temporal-specific manner. Thus, a circadian nuclear landscape seems to exist, whose interplay with metabolic pathways and clock regulators translates into specific transcriptional programs. Deciphering the molecular mechanisms that connect the circadian clock machinery with the nuclear landscape will reveal yet unexplored pathways that link cellular metabolism to epigenetic control.
Original languageEnglish (US)
Pages (from-to)6863-6870
Number of pages8
JournalPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume112
Issue number22
DOIs
StatePublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription'. Together they form a unique fingerprint.

Cite this