Chemoselective Hydrogenation of Nitroarenes Using an Air-Stable Base-Metal Catalyst

Viktoriia Zubar, Abhishek Dewanji, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

Abstract

The reduction of nitroarenes to anilines as well as azobenzenes to hydrazobenzenes using a single base-metal catalyst is reported. The hydrogenation reactions are performed with an air-and moisture-stable manganese catalyst and proceed under relatively mild reaction conditions. The transformation tolerates a broad range of functional groups, affording aniline derivatives and hydrazobenzenes in high yields. Mechanistic studies suggest that the reaction proceeds via a bifunctional activation involving metal–ligand cooperative catalysis.
Original languageEnglish (US)
JournalOrganic Letters
DOIs
StatePublished - Mar 23 2021

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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