Chemoselective Hydroboration of Propargylic Alcohols and Amines Using a Manganese(II) Catalyst

Aleksandra Brzozowska, Viktoriia Zubar, Ruth-Christine Ganardi, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The first manganese-catalyzed hydroboration of propargylic alcohols and amines as well as internal alkynes is reported. High regio- and stereoselectivity is achieved by applying 2 mol % of a manganese precatalyst based on the readily accessible bis(imino)pyridine ligand and MnCl2 as metal source. Propargylic alcohols and amines, as well as alcohols/amines and symmetric internal alkynes, were efficiently converted into the corresponding functionalized alkenes, which can serve as important and valuable intermediates for further synthetic applications such as cross-coupling reactions.
Original languageEnglish (US)
JournalOrganic Letters
DOIs
StatePublished - Mar 31 2020

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