Chemically induced pluripotent stem cells (CiPSCs): A transgene-free approach

Shigeo Masuda, Jun Wu, Tomoaki Hishida, Ganesh N. Pandian, Hiroshi Sugiyama, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.

Original languageEnglish (US)
Pages (from-to)354-355
Number of pages2
JournalJournal of Molecular Cell Biology
Volume5
Issue number5
DOIs
StatePublished - Oct 1 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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