Changes in the Arabidopsis RNA-binding proteome reveal novel stress response mechanisms

Claudius Marondedze, Ludivine Thomas, Christoph A Gehring, Kathryn S. Lilley

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

BACKGROUND:RNA-binding proteins (RBPs) are increasingly recognized as regulatory component of post-transcriptional gene expression. RBPs interact with mRNAs via RNA-binding domains and these interactions affect RNA availability for translation, RNA stability and turn-over thus affecting both RNA and protein expression essential for developmental and stimulus specific responses. Here we investigate the effect of severe drought stress on the RNA-binding proteome to gain insights into the mechanisms that govern drought stress responses at the systems level. RESULTS:Label-free mass spectrometry enabled the identification 567 proteins of which 150 significantly responded to the drought-induced treatment. A gene ontology analysis revealed enrichment in the
Original languageEnglish (US)
JournalBMC Plant Biology
Volume19
Issue number1
DOIs
StatePublished - Apr 11 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): CRG3–62140383
Acknowledgements: The research was funded by the Office of Competitive Research Grant Program, grant number CRG3–62140383, King Abdullah University of Science and Technology (KAUST).

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