Cellulose acetate membranes for transdermal delivery of scopolamine base

Fang Jing Wang, Yi Yan Yang*, Xian Zheng Zhang, Xiao Zhu, Tai-Shung Chung, Shabbir Moochhala

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Transdermal delivery is one of the most convenient drug administration routes. In this study, the cellulose acetate membranes were cast with acetone as a solvent at 22 and 40 °C. Polyethylene glycol (PEG, MW 600) was used as a pore-forming agent. The in vitro release rates of scopolamine base as a model drug through the membranes were evaluated in phosphate buffer solution (PBS, pH 7.4) at 32 °C. The membranes were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermal mechanical analysis (TMA) and thermogravimetric analysis (TGA). It was observed that the drug permeation through the cellulose acetate membranes was obviously affected by the incorporated PEG content and formed membrane morphology. There was no drug flux from the cellulose acetate membranes prepared without PEG. An increased PEG content resulted in a faster scopolamine release due to a more porous structure created. Both the membrane fabrication temperature and the PEG content can affect the thermal, mechanical and morphological properties of the resultant membranes. With the optimized fabrication conditions, linear in vitro release profiles of scopolamine over 3 days were achieved. The membranes developed would be useful for transdermal delivery of drugs.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalMaterials Science and Engineering C
Volume20
Issue number1-2
DOIs
StatePublished - May 31 2002

Keywords

  • Cellulose acetate membranes
  • Polyethylene glycol (PEG)
  • Scopolamine
  • Transdermal delivery

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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