Cellular uptake studies with β-peptides

Magnus Rueping, Yogesh Mahajan, Markus Sauer, Dieter Seebach*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

Translocation across the membrane into cells is possible for certain peptides and proteins. To investigate the structural requirements of β-peptides for this process, a series of fluorescein-labeled β-peptides has been synthesized and their cellular uptake into 3T3 mouse fibroblast cells determined by fluorescence microscopy (see picture). Polycationic β-peptides have been shown to internalize into cells, and accumulation in the cytosol and nucleus is observed.

Original languageEnglish (US)
Pages (from-to)257-259
Number of pages3
JournalChemBioChem
Volume3
Issue number2-3
DOIs
StatePublished - Mar 1 2002

Keywords

  • Arginine
  • Cellular uptake
  • Fluorescence microscopy
  • Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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