Cells and tissue imaging with digital holographic microscopy

Christian D. Depeursinge*, Etienne Cuche, Tristan Colomb, Pia Dahlgren, Anca M. Marian, Frederic Monfort, Pierre Marquet, Pierre J. Magistretti

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

6 Scopus citations

Abstract

The aim of Optical Digital Holography, applied to cells and tissue imaging, is to provide an accurate 3D imaging of biologic materials, down to the microscopic scale. The method has been developed to yield a very precise determination of cells and tissues morphology. Targeted accuracies are in the sub-micron range and allow for the observation of very small movements and deformations, produced, in particular, by depolarization of excitable cells and their metabolic activities. Direct imaging of tissue structures by the newly developed digital holography is deemed to offer unique investigation means in biology and medicine and attractive diagnostic capabilities.

Original languageEnglish (US)
Pages (from-to)134-138
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5143
DOIs
StatePublished - Jan 1 2003
EventNovel Optical Instrumentation for Biomedical Applications - Munich, Germany
Duration: Jun 24 2003Jun 25 2003

Keywords

  • Cell culture imaging
  • Functional imaging
  • Holography
  • Microscopy
  • Phase contrast

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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