Catalytic Ester and Amide to Amine Interconversion: Nickel-Catalyzed Decarbonylative Amination of Esters and Amides by C−O and C−C Bond Activation

Huifeng Yue, Lin Guo, Hsuan-Hung Liao, Yunfei Cai, Chen Zhu, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

An efficient nickel-catalyzed decarbonylative amination reaction of aryl and heteroaryl esters has been achieved for the first time. The new amination protocol allows the direct interconversion of esters and amides into the corresponding amines and represents a good alternative to classical rearrangements as well as cross coupling reactions.
Original languageEnglish (US)
Pages (from-to)4282-4285
Number of pages4
JournalAngewandte Chemie International Edition
Volume56
Issue number15
DOIs
StatePublished - Mar 15 2017

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