Catalytic asymmetric domino Michael-Henry reaction: Enantioselective access to bicycles with consecutive quaternary ceuters by using bifunctional catalysts

Magnus Rueping*, Alexander Kuenkel, Roland Fröhlich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

"Chemical Equotion Presentation" Domino catalysis: Two consecutive quaternary stereocenters, three functional groups, and four stereogenic centers have been created in the newly developed domino Michael-Henry reaction (see scheme) employing small amounts of a bifunctional organocatalyst.

Original languageEnglish (US)
Pages (from-to)4173-4176
Number of pages4
JournalChemistry - A European Journal
Volume16
Issue number14
DOIs
StatePublished - Apr 12 2010

Keywords

  • Cascade reactions
  • Domino reactions
  • Hydrogen bonds
  • Organocatalysis
  • Thioureas

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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