Catalytic asymmetric domino michael addition - Alkylation reaction: Enantioselective synthesis of dihydrofurans

Magnus Rueping*, Alejandro Parra, Uxue Uria, François Besselièvre, Estíbaliz Merino

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

A catalytic enantioselective synthesis of dihydrofurans has been developed. 1,3-Dicarbonyl derivatives react with (E)-β,β-bromonitrostyrenes in the presence of a chiral bifunctional thiourea catalyst providing mild and efficient access to diverse polysubstituted dihydrofurans in good yields and enantioselectivities.

Original languageEnglish (US)
Pages (from-to)5680-5683
Number of pages4
JournalOrganic Letters
Volume12
Issue number24
DOIs
StatePublished - Dec 17 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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