Catalytic asymmetric addition of aldehydes to oxocarbenium ions: A dual catalytic system for the synthesis of chromenes

Magnus Rueping*, Chandra M.R. Volla, Iuliana Atodiresei

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

A synergistic catalytic system for the first asymmetric addition of aldehydes to in situ generated prochiral oxocarbenium ions has been developed. The dual catalytic protocol allows the simultaneous activation of both electrophile and nucleophile and provides access to a variety of valuable chiral 2H-chromenes with excellent enantioselectivities.

Original languageEnglish (US)
Pages (from-to)4642-4645
Number of pages4
JournalOrganic Letters
Volume14
Issue number17
DOIs
StatePublished - Sep 7 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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