Cardiac Progenitor Cell Extraction from Human Auricles

Paolo Di Nardo, Francesca Pagliari

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

For many years, myocardial tissue has been considered terminally differentiated and, thus, incapable of regenerating. Recent studies have shown, instead, that cardiomyocytes, at least in part, are slowly substituted by new cells originating by precursor cells mostly embedded into the heart apex and in the atria. We have shown that an elective region of progenitor cell embedding is represented by the auricles, non-contractile atria appendages that can be easily sampled without harming the patient. The protocol here reported describes how from auricles a population of multipotent, cardiogenic cells can be isolated, cultured, and differentiated. Further studies are needed to fully exploit this cell population, but, sampling auricles, it could be possible to treat cardiac patients using their own cells circumventing rejection or organ shortage limitations.
Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherSpringer Nature
Pages145-154
Number of pages10
ISBN (Print)9781493967544
DOIs
StatePublished - Feb 23 2017

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

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