Carbohydrate-protein complex for specifically isolating metastatic circulating cancer cells

G. Simone, N. Malara, P. Neuzil, E. Di Fabrizio, A. Manz

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Isolation of metastatic circulating tumor cells (CTCs) is still a challenge as well as to develop a surveillance strategy for early cancer detection. The principal difficulty is the identification of the metastatic sub-population belonging to the heterogeneous circulating cells. Here we present carbohydrate use for specific binding assay to isolate metastatic circulating tumor cells (CTCs). In this assay we took advantage to explore the specificity of carbohydrate-protein complex responsible of the tumour cell extravasations, mimicking in vivo multivalent interactions. The assay resulted efficient in dealing CMCs (specificity of 68% and captures efficiency of 82%).

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages100-102
Number of pages3
Volume1
StatePublished - 2011
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

Keywords

  • Carbohydrate-protein complex
  • Early detection
  • Metastasis

ASJC Scopus subject areas

  • Control and Systems Engineering

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