Capacitive immunosensor for C-reactive protein quantification

Christos Sapsanis, Shilpa Sivashankar, Hesham Omran, Ulrich Buttner, Khaled N. Salama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Abstract

We report an agglutination-based immunosensor for the quantification of C-reactive protein (CRP). The developed immunoassay sensor requires approximately 15 minutes of assay time per sample and provides a sensitivity of 0.5 mg/L. We have measured the capacitance of interdigitated electrodes (IDEs) and quantified the concentration of added analyte. The proposed method is a label free detection method and hence provides rapid measurement preferable in diagnostics. We have so far been able to quantify the concentration to as low as 0.5 mg/L and as high as 10 mg/L. By quantifying CRP in serum, we can assess whether patients are prone to cardiac diseases and monitor the risk associated with such diseases. The sensor is a simple low cost structure and it can be a promising device for rapid and sensitive detection of disease markers at the point-of-care stage.
Original languageEnglish (US)
Title of host publication2015 IEEE 58th International Midwest Symposium on Circuits and Systems (MWSCAS)
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
ISBN (Print)9781467365581
DOIs
StatePublished - Oct 1 2015

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