Brain energy metabolism: Focus on Astrocyte-neuron metabolic cooperation

Mireille Bélanger, Igor Allaman, Pierre Magistretti*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1016 Scopus citations

Abstract

The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes - a type of glial cell - have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.

Original languageEnglish (US)
Pages (from-to)724-738
Number of pages15
JournalCell Metabolism
Volume14
Issue number6
DOIs
StatePublished - Dec 7 2011

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

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