Brønsted-acid catalyzed condensation-Michael reaction-Pictet- Spengler cyclization - Highly stereoselective synthesis of indoloquinolizidines

Magnus Rueping*, Chandra M.R. Volla

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A highly diastereoselective methodology for the efficient synthesis of functionalized indolo[2,3-a]quinolizidine skeletons in a one-pot operation has been developed. The protocol makes use of simple and inexpensive starting materials such as tryptamines, 1,3-dicarbonyl compounds and α,β- unsaturated aldehydes in the presence of a Brønsted acid catalyst.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalRSC Advances
Volume1
Issue number1
DOIs
StatePublished - Aug 7 2011

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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