Brønsted-acid-catalyzed activation of nitroalkanes: A direct enantioselective aza-henry reaction

Magnus Rueping*, Andrey P. Antonchick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


A direct asymmetric organocatalytic aza-Henry reaction has been developed in which a new bifuctlonal Bronsted-acid-catalyzed activation of nitroalkanes provides an efficient access to α,β-diamino acids with high dia- and enantioselectivities under mild and base-free reaction conditions.

Original languageEnglish (US)
Pages (from-to)1731-1734
Number of pages4
JournalOrganic Letters
Issue number9
StatePublished - May 1 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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