Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

Haizhou Yu, Xiaoyan Qiu, Suzana Pereira Nunes, Klaus-Viktor Peinemann

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

The design of micro-or nanoparticles that can encapsulate sensitive molecules such as drugs, hormones, proteins or peptides is of increasing importance for applications in biotechnology and medicine. Examples are micelles, liposomes and vesicles. The tiny and, in most cases, hollow spheres are used as vehicles for transport and controlled administration of pharmaceutical drugs or nutrients. Here we report a simple strategy to fabricate microspheres by block copolymer self-assembly. The microsphere particles have monodispersed nanopores that can act as pH-responsive gates. They contain a highly porous internal structure, which is analogous to the Schwarz P structure. The internal porosity of the particles contributes to their high sorption capacity and sustained release behaviour. We successfully separated similarly sized proteins using these particles. The ease of particle fabrication by macrophase separation and self-assembly, and the robustness of the particles makes them ideal for sorption, separation, transport and sustained delivery of pharmaceutical substances. © 2014 Macmillan Publishers Limited.
Original languageEnglish (US)
JournalNature Communications
Volume5
Issue number1
DOIs
StatePublished - Jun 17 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

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