Biodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging

Adah Almutairi, Steven J. Guillaudeu, Mikhail Y. Berezin, Samuel Achilefu, Jean M J Fréchet

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

The overproduction of acidic byproducts is implicated in the development of numerous diseases, and there is currently great interest in developing contrast agents that can image acidic tissue in vivo. Here we report a biodegradable pH-sensing near-infrared (NIR) nanoprobe capable of providing both fluorescence intensity amplification and lifetime information. The pH-sensing NIR nanoprobe is synthesized, in six high yielding and scalable steps, and functions within the tissue transparency window. Both fluorescence intensity and lifetime provided complementary physiological (low pH) and molecular (released fluorophore binding to albumin) information, respectively.

Original languageEnglish (US)
Pages (from-to)444-445
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number2
DOIs
StatePublished - Jan 16 2008
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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