Bignanoside A “A new neolignan glucoside” and bignanoside B “A new iridoid glucoside” from Bignonia binata leaves

Basma Khalaf Mahmoud, Mamdouh Nabil Samy, Ashraf Nageeb Elsayed Hamed, Usama Ramadan Abdelmohsen, Dina A. Hajjar, Yoshi Yamano, Sachiko Sugimoto, Katsuyoshi Matsunami, Mohamed Salah Kamel

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3 Scopus citations

Abstract

One new neolignan glucoside; bignanoside A (1) and one new iridoid glucoside; bignanoside B (2), and one new lignan rhamnoside; (-)-1yoniresinol 3α-O-α-L-rhamnopyranoside (3) reported for the first time, alongside with seven known compounds were isolated from Bignonia binata leaves. The structures of the isolated compounds were elucidated by various spectroscopic methods, including 1D and 2D NMR experiments, as well as HR-ESI-MS. Compound 2 had a potent DPPH radical scavenging activity with IC50 value of 18.34 ± 0.81 μM. Likewise, compounds 4 and 9 exhibited antitrypanosomal activity with IC50 value of 29.12 ± 1.21 and 17.80 ± 0.32 μM, respectively, against Trypanosoma brucei brucei S427.
Original languageEnglish (US)
Pages (from-to)200-205
Number of pages6
JournalPhytochemistry Letters
Volume35
DOIs
StatePublished - Dec 23 2019

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