Bacteriophage Lysin CF-301, a Potent Antistaphylococcal Biofilm Agent

Raymond Schuch, Babar Khalid Khan, Assaf Raz, Jimmy A. Rotolo, Michael Wittekind

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Biofilms pose a unique therapeutic challenge because of the antibiotic tolerance of constituent bacteria. Treatments for biofilm-based infections represent a major unmet medical need, requiring novel agents to eradicate mature biofilms. Our objective was to evaluate bacteriophage lysin CF-301 as a new agent to target Staphylococcus aureus biofilms. We used minimum biofilm-eradicating concentration (MBEC) assays on 95 S. aureus strains to obtain a 90% MBEC (MBEC90) value of
Original languageEnglish (US)
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number7
DOIs
StatePublished - May 1 2017

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